Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia

Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by multiple known recurrent genetic aberrations that inform prognosis, the most common being hyperdiploidy.

Citation:
Simpson APA, George CE, Hui HYL, Doddi R, Kotecha RS, Fuller KA, Erber WN. Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia. Cells. 2025;14(2).

Keywords:
Acute lymphoblastic leukaemia; hyperdiploid; imaging flow cytometry; immuno-flowFISH

Abstract:
Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by multiple known recurrent genetic aberrations that inform prognosis, the most common being hyperdiploidy.