A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experimental models. With cancerspecific expression, functional dispensability for normal development, and an unleveraged prooncogenic function in mRNA homeostasis, IGF2BP3 represents an excellent target.

Citation:
Jaiswal AK, Scherer GM, Thaxton ML, …….. Kotecha RS, Sanford JR, et al. A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity. Haematologica. 2025;10.3324/haematol.2025.288221.

Keywords:
leukemia; children's cancers; RNA-binding; molecule inhibitor

Abstract:
The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experimental models. With cancerspecific expression, functional dispensability for normal development, and an unleveraged prooncogenic function in mRNA homeostasis, IGF2BP3 represents an excellent target.