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Early disease surveillance in young children with cystic fibrosis: A qualitative analysis of parent experiences

Sensitive measures of early lung disease are being integrated into therapeutic trials and clinical practice in cystic fibrosis (CF). The impact of early disease surveillance (EDS) using these novel and often intensive techniques on young children and their families is not well researched.

Aquatic high intensity interval training to improve aerobic capacity is feasible in adolescents with cerebral palsy: pilot randomised controlled trial

To investigate feasibility of aquatic high intensity interval training for adolescents with cerebral palsy, who can ambulate independently but may choose a mobility aid in some circumstances.

Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children

These findings suggest that genetic variants at the VDR locus may play a role in acute wheeze/asthma severity in children

Acute infection and long term follow-up of people with HIV

Investigators: Peter Le Souef Project description There have been almost no studies of the first illness caused by HIV infection. We have recruited

Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze

Ingrid Pat Laing Holt BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Head, Children's Respiratory Science Emeritus Honorary Researcher 6319 1828 Ingrid.laing@

Children’s Respiratory Science

The Children’s Respiratory Science group’s research has an emphasis on mechanisms of respiratory health in children including those that predict and underpin acute viral respiratory infections in children.

LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children during acute virus-associated exacerbations and later during convalescence.

What codes the development of asthma in children?

An NHMRC grant exploring epigenetic factors that affect wheezing and asthma development.

Future Child Health

The greatest threat to children’s health in the future is environmental change, including climate change. The Future Child Health project aims to quantify how current and future environmental changes affect child health.

Mechanisms of Acute Viral Respiratory Illness in Children (MAVRIC)

Large numbers of children need emergency medical treatment each year for respiratory illnesses, particularly for wheezing and asthma.