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Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and AdolescentsSerotonin (5-HT) is widely implicated as a key neurotransmitter relevant to a range of psychiatric disorders and psychological processes. The role of central nervous 5-HT function underlying these processes can be examined through serotonergic challenge methodologies.
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Developing a smartphone application to support social connectedness and wellbeing in young people with cystic fibrosisThis study developed and tested a highly usable, and moderately acceptable, smartphone app to improve the psychosocial health of young people living with CF
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A preliminary investigation of the effects of prenatal alcohol exposure on facial morphology in children with Autism Spectrum DisorderWhile early exposure to alcohol may influence the development of facial structures, it does not appear to be associated with ASD phenotypic variability
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Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal CognitionNonverbal IQ is not on the same causal pathway as language impairments
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Preoperative identification of children at high risk of obstructive sleep apneaObstructive sleep apnea poses as an anesthetic challenge, and it is a well-known risk factor for perioperative adverse events
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Volatiles or TIVA: Which is the standard of care for pediatric airway procedures? A pro-con discussionThis pro-con discussion examines both volatiles and TIVA, from the perspective of effectiveness, safety, cost, and environmental impact,
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Association of suicidal behavior with exposure to suicide and suicide attempt: A systematic review and multilevel meta-analysisprior exposure to suicide and prior exposure to suicide attempt in the general population are associated with increased odds of subsequent suicidal behavior
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Nasal delivery of a commensal Pasteurellaceae species inhibits nontypeable Haemophilus influenzae colonisation and delays onset of otitis media in miceWe have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo
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Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational ageWe identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues
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Timeliness of signal detection for adverse events following influenza vaccination in young children: a simulation case studyActive vaccine safety surveillance leading to rapid detection of a safety signal would likely have resulted in earlier suspension of Fluvax from the vaccination programme